Neurodegenerative disorders (NDDs) impact a significant number of the US and the global population and are the leading cause of disability and morbidity in the US. There is a long history of failed attempts to develop effective therapies, and currently, there are no treatments that can prevent, slow down, or cure NDD.
Here we present an in-depth analysis of the current development pipeline for AD, PD, HD, and ALS by phase and mechanism of action with the focus on symptomatic versus disease-modifying approaches. Furthermore, we provide insights on the challenges in drug development for NDD and how they can be addressed.